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Effects of epilepsy on neural activity in mice fluctuate with reproductive cycle, study finds

Mice with epilepsy have altered patterns of neuron activity in the portion of the brain that controls the reproductive endocrine system, University of Illinois researchers report in a new study. Furthermore, the differences in neuron activity in female mice fluctuate across the reproductive cycle, the team found.

Study: Online positive psychology exercises improve quality of life in hemodialysis patients

Kidney dialysis patients who engage in technology-based positive psychology exercises during their treatments may significantly improve their depressive symptoms and quality of life, a new study found.

Study: Damaged liver cells undergo reprogramming to regenerate

In Greek mythology, Zeus punishes the trickster Prometheus by chaining him to a rock and sending an eagle to eat a portion of his liver every day, in perpetuity. It was the right organ to target – the liver has the ability to regenerate itself, though not overnight nor for eternity.

New research conducted by biochemists at the University of Illinois has determined how damaged liver cells repair and restore themselves through a signal to return to an early stage of postnatal organ development.

Study: Kidney stones have distinct geological histories

A geologist, a microscopist and a doctor walk into a lab and, with their colleagues from across the nation, make a discovery that overturns centuries of thought about the nature and composition of kidney stones. The team’s key insight, reported in the journal Scientific Reports, is that kidney stones are built up in calcium-rich layers that resemble other mineralizations in nature, such as those forming coral reefs or arising in hot springs, Roman aqueducts or subsurface oil fields.

Discovery: Mechanical properties of viral DNA determine the course of infection

A new study reveals a previously unknown mechanism that governs whether viruses that infect bacteria will quickly kill their hosts or remain latent inside the cell. The discovery, reported in the journal eLife, also may apply to viruses that infect humans and other animals, the researcher said.

Color-changing sensor detects signs of eye damage in tears

A new point-of-care rapid-sensing device can detect a key marker of eye injury in minutes – a time frame crucial to treating eye trauma.  

University of Illinois researchers developed a gel laden with gold nanoparticles that changes color when it reacts with a teardrop containing ascorbic acid, released from a wound to the eye. In a new study published in the journal Biosensors and Bioelectronics, the researchers used the sensor, called OjoGel, to measure ascorbic acid levels in artificial tears and in clinical samples of fluid from patients’ eyes. 

A professor not afraid to cross academic boundaries

Illinois professor Ruby Mendenhall is focused on issues of poverty, inequality and violence, but crosses many academic boundaries in search of answers.

New CRISPR technique skips over portions of genes that can cause disease

In a new study in cells, University of Illinois researchers have adapted CRISPR gene-editing technology to cause the cell’s internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. This gives researchers a way not only to eliminate a mutated gene sequence, but to influence how the gene is expressed and regulated. Such targeted editing could one day be useful for treating genetic diseases caused by mutations in the genome, such as Duchenne’s muscular dystrophy, Huntington’s disease or some cancers.

Nowhere to hide: Molecular probe illuminates elusive cancer stem cells in live mice

After a primary tumor is treated, cancer stem cells may still lurk in the body, ready to metastasize and cause a recurrence of the cancer in a form that’s more aggressive and resistant to treatment. University of Illinois researchers have developed a molecular probe that seeks out these elusive cells and lights them up so they can be identified, tracked and studied not only in cell cultures, but in their native environment: the body.

Study explores risk factors linked to chikungunya and dengue outbreaks

In one of the largest studies of its kind, researchers analyzed chikungunya and dengue outbreak data from 76 countries over a period of 50 years, focusing on regions across the Indian Ocean that are hard hit by these and other mosquito-borne infectious diseases.

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