Main Content

You are here

Policy: Use of Sedatives, Analgesics, and Anesthetics in Animals Used in Research and Teaching (IACUC)

Policy: Use of Sedatives, Analgesics, and Anesthetics in Animals Used in Research and Teaching (IACUC)


It is difficult to assess pain and distress in animals, so procedures that cause pain or distress in humans should be assumed to cause similar affects in animals. Sedation, analgesia, or anesthesia should be administered if animals may experience more than momentary or slight pain or distress unless there is scientific justification for not doing so. The attending veterinarian is responsible for ensuring that adequate sedation, analgesia, or anesthesia is provided.


When animals may experience more than momentary or slight pain or distress, the animal care and use protocol must include a detailed description of how this will be assessed and alleviated. Investigators must ensure research personnel are adequately trained to assess pain and distress in the species being utilized. When animals are subjected to major surgery, routine provision of postsurgical analgesia is required. The investigator must provide the Institutional Animal Care and Use Committee (IACUC) with a scientific justification for withholding sedatives, analgesics, or anesthetics or for any deviations from the recommendations of the veterinary staff. The justification should include evidence that the agents would compromise scientific aspects of the research protocol. Investigators are strongly encouraged to consult with the veterinary staff during the protocol planning period about the use of drugs for controlling pain and distress.

Agricultural Animal Care and Use Program (AACUP) and Division of Animal Resources (DAR) and Clinical Veterinary Staff:
The veterinary staff must approve the proposed methods and use of agents to prevent or alleviate pain or distress in experimental animals. The AACUP and DAR veterinary staff review animal care and use protocols and consult with investigators to arrive at appropriate methods of treatment that meet the clinical needs of the animals and do not compromise the scientific integrity of the experiments.

In the event of unanticipated pain or distress that is protocol-associated or arises from spontaneous illness or injury, the AACUP or DAR veterinary staff must be notified immediately. The respective AACUP or DAR veterinarian is responsible for determining the cause of pain and instituting appropriate ameliorative therapy. AACUP and DAR veterinarians are authorized to make independent emergency decisions concerning the treatment regimen of animals experiencing unalleviated pain or suffering. This authority is delegated to AACUP or DAR veterinarians attending to animals under the auspices of the University of Illinois IACUC. Such animals must be provided appropriate veterinary care or be humanely euthanized unless this is in direct conflict with experiment goals described in an IACUC-approved protocol. Whenever possible, the investigator is consulted prior to initiating treatment or euthanasia, but the primary consideration is always the animal’s welfare.

Institutional Animal Care and Use Committee:
The IACUC has ultimate responsibility for ensuring that pain and distress in research animals is limited to that which is necessary in the course of approved experimentation. This includes review and approval of methods and agents to prevent and alleviate pain and distress, and the PI's demonstrated effort to find alternatives to potentially painful procedures, even when the intention is to alleviate such pain. Committee decisions will be based on regulatory requirements as well as advice from the veterinary staff and the investigators. At least every three years, the IACUC will review protocols that involve pain or distress to assess methods and agents being used and deviations (if any) from this policy.

Approved 12/3/1998
Updated: 6/2/2020


Principal Investigators

I'm looking for...

Limited Submission Information

Human Subject Usage

Sponsored Research